Process of Developing a thesis or argument Essay Example

Process of Developing a thesis or argument Essay Part 1: Summary Process of Developing a thesis or argument A thesis refers to an argument that states a position on a topic, describes the subject, and proves the issue. It indicates a precise statement and tries to prove the argument. The thesis helps in clarifying the idea behind the writing and gives a reader a hook to stick to while going through the document. It should be specific, clear, and original. For example, a thesis statement in the form of Humanity must save the Elephants, is universal and too general. A revised statement thesis on the same need to read, Elephants are gradually becoming an endangered species, humanity need to save them and stop their extinction. The best strategy is avoiding creating from a source or direct quotation; it need be distinct, memorable, and impressive. A definite attention grabber should form the basis of a credible thesis. We will write a custom essay sample on Process of Developing a thesis or argument specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Process of Developing a thesis or argument specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Process of Developing a thesis or argument specifically for you FOR ONLY $16.38 $13.9/page Hire Writer In coming up with a plausible thesis, a writer needs to find a clear focus that will be in a position to explore the topic at hand. The thesis statement need only be one or two sentences. It provides the theme of the paper and gives the position of the writer on the topic under argument or analysis. The second important tip is to look for an outline of looking closely at the evidence to be presented.The framework will help in the creation of the body of the paper, where all possible evidence is provided to prove the thesis statement. The process involved in creating, developing, and formulating a thesis entails constructing a credible argument that is in line with the evidence that will be presented in the body of the paper. In forming, the argument, one that will involve reading, putting on paper, and critical thinking. It is important to first come up with a purpose statement that briefly sketches the background, and maybe the history of the subject matter. For example, if an assignment requires a brief history of the Conservative party and its political influence in the country since 1900, the purpose statement should aim at giving a brief history and sketch of the party and ways to which it influenced political decisions and policies of the party and the country at large. The purpose statement will narrow down the argument and strengthen the main idea of the paper. After coming up with the purpose statement, the next step is coming up with the main idea, a summary of the entire essay or paper that will after that give way to formulating a list of ideas that may be included in the journal. After coming up with several ideas, it is important to group them and have a link to each of the ideas to the central theme of the paper. After having a central idea linking up all the ideas of the subject, a formula can after that be applied to arrive at a possible and vigorous argument or thesis statement. For example, the following statements can be used to reach out at a strong hypothesis; Although most Republicans maintain thatthe country seems to hold on to the idea of a Political mediocrity is often a result of a more dividedbrought about by the lack of political will in applies and .to shows that The above process offers a framework for drafting the outline of an argument with the hypothesis, serving only as a planning tool. To keep the paper cohesive, it is important to read the evidence and keep a reader focused. The main elements that will form the basis of the thesis are the conclusion and the evidence provided. By focusing on the central point and case of the paper, the paper will provide a better-refined thesis statement. An assignment without a particular problem statement is challenging and may call for additional information to formulate a thesis statement. However, in such situation, as it is important to formulate the argument around the central idea of the assignment. In this case, the most important thing is to get to the bottom of the assignment and come up with a possible scenario of a challenge or problem. Or, approach the assignment from a solution perspective without considering the existence of a potential problem. Not all thesis statements require a problem to formulate an argument statement. An argument statement can be developed by taking a different approach or side of the given assignment. For example, an assignment that is based on a scenario in which a character is expected to offer guidance on the flow of the essay may call upon the writer to base the argument statement on a possible or alternative position not taken by the character in question. Then after taking a different posi tion from the character in question, it is possible to come up with a thesis statement. The assignments provided in the class have been diverse and broad-based, ranging from argumentative essays to plain papers, descriptive, and fact based articles. The majority of the assignments have been problem-oriented majorly tackling major socioeconomic and political issues of the society. For example, most of the articles revolved around social issues affecting the society in general, such as economic policies affecting the middle-class group, government policies such as Medicare and education strategies. Additionally, some of the problem-oriented assignment environmental issues such as global warming, solutions to educational diversity, and religious conflicts. The assignment concentrated more on coming up with tangible clarifications and possible solutions to socioeconomic and political issues affecting the majority of citizens in the 21st century. Most of the writing focused on finding solutions and providing in-depth clarification on societal issues such as gun control, suicide amongst teenagers, the effects of the social media, government provisions, immigration legislations, and homelessness, in addition to housing challenges in urban centers. Although there is not much difference in the problems handled in the assignments, one aspect that stood out was the research involved in the entire exercise in which the primary goal was to find solutions and clarification on some of the problems affecting the society. Majorly, most of the problems I tackled tend to identify, expound, and do in-depth research into the problems. Over the course of my academic career, while posing possible questions behind a given problem such as gun control or violence amongst college going students, I challenged the societys preparedness in tackling the habit. At the same time identified some of the aspects of the issue that has posed problems for the society over the years. Instructions presented often tend to focus on the identification of the subject, probing the challenge, and looking at how the community has responded to it over the years. In some cases, the instructions call upon identification of solutions or possible strategies for handling the issues. My introductions first approach assignment from the central aspect of the idea presented. For example, an assignment requiring an analysis of the effects of a Republican-dominated Congress would first dwell on an even and balanced House, in which the number of Republicans and Democrats are equal. From this perspective, it will be much easier to develop an argument considering that I have in mind, how a balanced House would operate and pass legislations. Or a different argumentative assignment on the effect of education on consumption of processed and fast foods. My approach to the paper would entail figuring out what is behind the processed and fast foods that call upon education. From this perspective, it is possible to formulate and bring together the three concepts; that is the education, consumers, and the processed or fast foods. The three concepts would form my structural aspect of the thesis with a greater emphasis on putting them together to build an argument on the relations hip between the three elements. Part 2: Reflection It is fun and exciting to discover that writing is inspired by problem-solving abilities. Although the notion of putting ideas into writing while at the same time solving a problem sounds remote, it is worth noting that, a problem is a mind trigger, a stimulant in thinking, and a way in which the mind is utilized to engage with putting words together to form a coherent argument. The urge to find a solution, the motivation to develop a reasonable hypothesis come out as one interesting aspect of writing. It is no doubt that writers tend to focus on socioeconomic and political aspects of the society. Even though their approach is only theoretical, it is founded on the ability to translate overwhelming issues into issues that can be solved, and solutions established based on articulating thinking and formulation of ideas. It is also interesting that engaging the mind logically towards different scenarios, forms the cornerstone to coming up with a possible solution and ways of going aroun d formulating a strong argument. Additionally, from the reading, it is no doubt that problems form part of every individual life and the society as a whole. Developing an open approach towards problem-solving constitutes the basis of writing and is often the basis of every urge to find a solution to a problem. On the other hand, engaging in An argument and formulating a hypothesis remains key to developing a framework for finding a solution to a given problem. The reading further highlights the need for a precise formation of ideas and strategic approaches towards writing, a concept that augments writing skills beyond the problem-solving. It is thus interesting that while one may focus on improving ones writing skills, it, on the other hand, strengthens ones cognitive abilities such as confronting challenges in a methodological manner. Its interesting how a single problem can lead to several questions. It is interesting to note that a single problem can give rise to multiple problems putting unnecessary strain on a single issue that initially appeared non-technical. However, the beauty of writing as portrayed in the reading is the inherent ability of a writer to transcend from a problem seeker to a problem solver through and by in-depth research, questioning, and presentations of different problems. As a writer, able to handle several issues, it is interesting how one can weave through multiple scenarios and present a professional paper by and through in-depth questioning and analysis. It thus gives a moral issue worth addressing and a credible question that can offer excellent solutions. To master the writing skills, it is interesting that it involves sacrifice and determination, just as other endeavors. Problems thus form the basis and foundation of writing, offering a writer the opportunity to analyze, research, think, and carry out an in-depth clarification on a socioeconomic problem with the aim of providing a solution the myriad challenges that one may counter. The article not only expos es a writer in the world of challenges and technicalities but also presents an opportunity to find solutions to the many tests in the academic and social field. Another aspect that stands out interestingly, is the concept of knowledge. It is interesting that no one has the monopoly over knowledge and according to the reading, both the professional researcher and the layman in the street have same and credible knowledge worth giving attention. Despite the variation in the two types of knowledge, both minds, the researcher, and the street urchin have proof and evidence on the body of knowledge they subscribe to while considering all aspects of a given scenario. It stands out as strange, how the two may be right in their different opinions while maintaining the inner dimension of an argument or situation. The problems and challenges presented raise vital questions that are important in providing different approaches, a key factor that helps in problem-solving. One unique aspect of the problems presented in the article is that all of them involved various steps in developing the hypothesis, or argument. Most of the texts arrived at a solution fr om multiple perspectives, but one central theme that stood out is that the argument presented formed part of the solution. For example, the argument of organ trading, despite differing opinions, the formulated hypothesis presented focuses more finding a solution within the framework of the formulated argument. The entire argument of the paper simply supports the formulated thesis with a little added information or details. Par 3: Scavenger Hunt From the Mercy database, I found an article on research tips that focuses on topic selection, locating resources, assembling the contents, and formatting the entire document in a given format. The study forms an important aspect of writing at is entails getting down to searching for writing materials before putting down everything on paper. Although research tips vary and are wide, the tips presented offers vital lessons on assembling and putting together information critical in formulating an argument or hypothesis. Research forms the argument body of any thesis statement, and to come up with a credible paper; the paper body should form the central aspect of the thesis statement. A coherent thesis statement and a credible argument in the body makes a paper or assignment worthy of presentation. Below is the screenshot of a mercy database from Mercy College of Health Sciences. Source Research Tips. Mercy College of Health Sciences, www.mchs.edu/Academics/Library/Research-Tips. Accessed 17 Apr. 2017.

Defining Programming Language

Defining Programming Language A programming language is used to write computer  programs including applications, utilities, and systems programs. Before the Java and C# programming languages appeared, computer programs were either compiled or interpreted.   A compiled program is written as a series of humanly understandable computer instructions that can be read by a  compiler  and  linker  and translated into  machine code  so that a computer can understand and run it. Fortran, Pascal, Assembly Language, C, and C programming languages are almost always compiled in this way. Other programs, such as Basic, JavaScript, and VBScript, are interpreted. The differences between compiled and interpreted languages  can be confusing. Compiling a Program The development of a compiled program follows these basic steps: Write or edit the programCompile the program into machine code files that are specific to the target machineLink the machine code files into a runnable program (known as an EXE file)Debug or run the program Interpreting a Program Interpreting a program is a much faster process thats helpful for novice programmers when editing and testing their code. These programs run slower than compiled programs. The steps to interpret a program are: Write or edit the programDebug or run the program using an interpreter program Java and C# Both Java and C# are semi-compiled.  Compiling Java generates bytecode that is later interpreted by a Java virtual machine. As a result, the code is compiled in a two-stage process.   C# is compiled into Common Intermediate Language, which is then run by the Common Language Runtime part of the .NET framework, an environment that supports just-in-time compilation. The speed of C# and Java is almost as fast as  a true compiled language. As far as speed goes, C, C, and C# all are sufficiently speedy for games and operating systems. Programs on a Computer From the moment you turn on your computer, it is running programs, carrying out instructions, testing  RAM and accessing the operating system on its drive. Each and every operation that your computer performs has instructions that someone had to write in a programming language. For example, the Windows 10 operating system has roughly 50 million lines of code. These had to be created, compiled and tested; a long and complex task. Programming Languages Now In Use Top programming languages for PCs are Java and C with C# close behind and C holding its own. Apple products use Objective-C and Swift programming languages. There are hundreds of small programming languages out there, but other popular programming languages include: PythonPHPPerlRubyGoRustScala There have been many attempts to automate the process of writing and testing programming languages by having computers write computer programs, but the complexity is such that, for now, humans still write and test computer programs. The Future for Programming Languages Computer programmers tend to use programming languages they know. As a result, the old tried-and-true languages have hung around for a long time. With the popularity of mobile devices, developers may be more open to learning new programming languages. Apple developed Swift to eventually replace Objective-C, and Google developed Go to be more efficient than C. Adoption of these new programs has been slow, but steady.

Discrimination In Gender Essay Example | Topics and Well Written Essays - 2500 words

Discrimination In Gender - Essay Example Several people would disagree that females should not even be functioning as it is. Countless individuals consider that a woman's position is only inside their dwellings. Conceivably that is the principle in numerous societies. It would appear to be advantageous to contain at least a parent within the home taking care of the children more willingly that situating them inside a daycare institution. Customarily the husband is positioned to be the worker of the family unit, although, with price increasing rates, it is ever more essential to drive the wife to go out and find a job as well. Women ought to be dealt with as the same and be compensated the same as that with a man if he would be in the similar position. Gender role distinctiveness reveals the ideological disagreements underlying the prevailing gender representation within North American civilization. That representation directs us to consider that female, as well as male attitudes, are the outcome of publicly directed hormona l directives which denotes that females may want to contain children and may consequently find themselves somewhat dependent and reliant on males for back up and safeguarding. The representation declares that males are inherently insistent and viable and therefore will dictate above females. The societal hegemony of this principles guarantees that every one of us is brought up to perform gender functions which will substantiate this idea of the natural world of the sexes. Natural confirmation is evasive about the foundation of gender position.

UK Constitutional Law (United Kingdom) Assignment

UK Constitutional Law (United Kingdom) - Assignment Example The legislations are however not without issues, as demonstrated in the Jackson v Attorney General [2005] case regarding the legality of the application of Parliament Acts of 1911 and 1949 to pass the Hunting Act, making it illegal to hunt wild animals using dogs, except in very limited circumstances. 6The case was heard by a Divisional court and later passed on the court of appeal. The court of appeal decision was that constitutional changes could not be passed under the parliament act of 1911. 2The legal issues raised in this case is that any legislation done under the parliament Act of 1911 was not primary, but a subordinate one. The legislative power wielded by the Act was not limited, and thus was open to statutory interpretation. Upon reaching the decision, the judges raised the issue that the Act did not authorize the House of Commons to change or remove any conditions on which the law-making power is based. 6 The judges observed that the 1911 Act was wide to authorize some am endments of the commons law making power, contrary to the 1949 Act, which was observed to be substantial and significant. 6The discussion by the judges was that it was highly unlikely that the House of Commons could contemplate to use the Act to enact a legislation that the House of Lords had not consented to or to abolish the House of Lords completely. 2 If however, the House of Commons had such intentions, then it would be seen as contrary to the intentions of the parliament, when it was enacting such legislations. This gives the opinion that the 1911 act was much ambiguous, and require situational interpretation for its effective applicability. The roots of the two legislations can be traced back to the Budgeting done in the year 1909, which proposed the taxation of lands, with the ideas that a land tax should be introduced to raise budget money. The conservatives, who were mainly the large landowners opposed the proposal and saw its downfall through the House of Lords where they wielded immense power. Consequently, there was a perceived need to limit the powers of the House of Lords, through granting the House of Commons more power, most significantly the power to pass legislations without seeking the approval of the House of Lords. 1The agenda of the refused budget proposal become the bottom-line of the 1910 elections, where the liberals sought to limit the powers of the House of the Lords, when they got back to parliament t after the elections. This was eventually to happen, a milestone that saw the power of the House of Lords, to control and scrutinize all legislations and give their approval before any legislation was passed to a law curtailed. The provisions of Parliament Acts of 1911 underlined the fact that the House of Lords no longer had powers to veto any legislation emanating from the House of Commons. The only exception granted was on the issue of extending the maximum term of the parliament from to over five years. 2 The effect of this was to scrap off the powers of the House of Lords, leaving them with only an authority to delay bills but not to reject

Information and Data Handling Coursework Example | Topics and Well Written Essays - 1000 words

Information and Data Handling - Coursework Example My work however, which includes accessing the better place my family is going to live in London will be availed in relation to the budget and the affordability of time both for me and my siblings attending schools and my father who need to catch up the train in time while going to work (Ladley, pp.45). However, choice of different methods for collecting data in regards to which place my family will live, either in Ealing or Slough, will be influenced by the strategies, variable, accuracy point and skills behind the data collection that I will avail. This however, will include the use of questionnaires, interviews, direct observation and reports that will give me direct measurements towards the acquisition of the better area my family is going to live.  Questionnaires can be done online by the use of the school database system. I will engage and post questionnaires within my school account to reach my fellow students who leave either in Ealing or Slough to give verdict on how much r enting a three bedroom house cost, the cost of transport to school, effectives in regards to time and general the cost of life in this two areas (Wheelan, pp. 14-25). In addition, direct observation can be of more help since travelling to these areas will give me a clue on how much it cost in transportation and living standards. This however, triggers the use of direct measurements and interviews aspect.   Collect data on the renting cost of 20 three bed roomed houses in Slough and Ealing. You will need to use Estate Agents Websites.

Discovery of a Novel Oral Antithrombotic Drug Apixaban

Discovery of a Novel Oral Antithrombotic Drug Apixaban Shuangyu Ma Background Thrombosis, which is generally defined as the formation of blood clot inside blood vessels, is a major health issue in western world. Thrombosis associated disease, such as ischemic stroke and high blood pressure, remain to be the leading causes of morbidity and mortality each year in developed countries [1]. To make things worse, thrombosis is also known as a chronic disease with episodic recurrence [2]. According the American Heart Association, thirty percent of the patients diagnosed with venous thromboembolism develop recurrence within the next 10 years [2]. The balance between thrombosis formation and bleeding is prudently regulated by the blood coagulation cascade, one of the most delicate systems in human body (figure 1, [3]). The signal transmission and amplification along the cascade was conducted by a series of trypsin-like serine proteases with high specificity, often referred as zymogens [4]. The zymogens are cleaved by the previous coagulation factor to become activated proteases, which can thereby cleave the next zymogen along the cascade and achieve the signal amplification. Blood coagulation process can be triggered by intrinsic pathway or extrinsic pathway; both are followed by the activation of common pathway. The prothrombin is then cleaved by activated factor X to generate thrombin, eventually lead to the formation of stable fibrin clot. Fig 1. Blood coagulation cascade: (figure extracted from Haematology (2nd edition) by C. J. Pallister and M. S. Watson [4]) Until now, the most well-known oral anticoagulant is warfarin, which is the current standard therapy for clinic thrombosis treatment and prevention. Despite its widely application, warfarin has a huge draw back on its dosing issue. Many of the coagulation factors, including factors II, VII, IX and X are Vitamin K dependent; the ÃŽ ³-carboxylation by Vitamin K is essential for their biological activity. Targeting on vitamin-K conversion cycle, warfarin produces an anticoagulation effect by reducing activities of the four vitamin K-dependent coagulation factors. However, the responses to warfarin can be interfered dramatically by genetic and environment factors, such as the common mutation on cytochrome P450 encoding gene, disease states variation, drug-drug interaction or even diet change [5]. Hence, warfarin treated patients need blood test regularly (often once a week or even worse) to determine a safe dosage case by case. Despite handling with great cautious, the anticoagulant-asso ciated intracerebral hemorrhage keeps increasing [2]. Thus, many efforts have been put on developing a novel antithrombotic drug with low risk and high potency. From lead to drug: the development of apixaban The drug Apixaban, approved by FDA in 2012 for thromboembolism treatment and prevention, is developed by Pfizer and Bristol-Myers Squibb to serve as an optimized risk-benefit oral anticoagulant. The mechanism of apixaban is entirely different with warfarin it specifically targets on activated coagulation factor ten (FXa), rather than vitamin K. Several clinical trial has proved its higher efficacy compared to asparin and lower risk compared to warfarin treatment [6]. Given the central position in the blood coagulation cascade, FXa evolved as an attractive drug target for developing anticoagulants. The DuPont Merck Pharmaceutical Company first launched a high throughput screening on FXa inhibitor in 1997 [7]. Because of the substrate similarity between FXa and the GPIIb/IIa receptor, they screened the compound library which was originally designed to be GPIIb/IIa receptor antagonist. A hit was found with low micromolar FXa affinity (coumpound 1, Ki= 38.5 ÃŽ ¼M). However, most of the reported FXa inhibitor in literature at that time posse the bisamindinoaryl structure, such as 2 and 3 (figure 2a). Inspired by these compounds, they modified the hit to be bisamidines and obtained the first list of leads (including compound 4), as shown in figure 2b. Aiming at a higher potency, molecular modeling studies were conducted to further optimize the lead compound, which resulted in the removal of methylene unit between the isoxazoline ring and the amidine carbonyl together with the à ¯Ã¢â‚¬Å¾Ã†â€™ substitution to the carbonyl. After the comparison of different substitution groups, they obtained compound 5 with Ki of 94 nM (Figure 3) [7]. Fig 2 a. The structure of hit compound and several known FXa inhibitor b. The bisamidine lead compounds (figure extracted from [7]). Fig 3. Effects of the amidine group position and à ¯Ã¢â‚¬Å¾Ã†â€™ substitution (figure extracted from [7]) However, as an oral drug candidate, this dibasic lead compound might not have good oral absorption due to its hydrophilicity. Therefore, the next goal is to reduce its basicity by replacing one of the amidine groups with a neutral species. The molecular modeling of compound 5 bound to FXa indicated that the p-amidine group fits in an hydrophobic aryl-binding pocket of FXa, which is consist of three aromatic residues (Trp215, Tyr99 and Phe174, figure 4a) [8]. Therefore, it is possible to replace the p-amidine with aromatic functional groups without largely interrupt the affinity. They employed a biaryl group and obtained compound 6 with only 2-fold decrease in potency. Further investigation on different substitution at the terminal phenyl ring resulted in large enhancement on potency, such as compound 7 (Ki = 6.3 nM). (Figure 4b) Fig 4 a. Effects of substitutions on terminal phenyl ring (figures extracted from [8]). b. Chemical structure of compound 6 and 7 Nevertheless, another concern emerged to be the metabolic instability, as compound 7 bears an ester side chain, which is labile to esterase once it gets inside human body. Since the corresponding acid metabolite is three-fold less potent than the original ester [9], replacing the ester side chain appears becomes the imperative next step. Again, a list of compound 7 analogs bearing different side chains were synthesized and tested. Among all the functional groups, tetrazole substitution was found to be most potent, and compound 8 (Ki= 0.52 nM) was developed with additional modification on the biaryl ring motif (figure 5a). Variation on the position of amide moiety attachment and isoxazoline aromatization resulted in compound 9 (Ki= 0.15 nM, figure 5b) [10], while further investigation on a series of five-membered heterocyclic ring gives compound 10 with equal potency (Ki= 0.15 nM, figure 5c) and lower basicity [11] . Fig 5. Chemical structure of compound 8, 9 and 10 Despite the high potency and selectivity, compound 10 is still far from perfect due to potential mutagenicity of the biarylanilines motif [12]. Therefore, the cleavage of amide bond must be prevented by either ligating or eliminating the nitrogen (figure 6). Compound 11 was developed to have the optimized pyrazole with an even higher FXa affinity (Ki = 0.03 nM). After the scaffold was settled, more compound 11 analogs with various substitution groups and terminal aromatic rings were synthesized and compared to afford the final drug candidate as compound 12 (apixaban, Ki= 0.08, figure 7a) [1]. The optimized drug selectivity towards FXa was shown in figure 7b. The therapeutic index of the final drug compared to warfarin was demonstrated in rabbit thrombosis models and shown figure 7c) [6]. The drug candidate was sent for preclinical studies followed with several clinic trials, and eventually approved by FDA for venous thromboembolism prevention after hip/knee replacement and artrial fibrillation treatment. Another clinical trial for acute venous thromboembolism is still in progress. Fig 6. Compound 11 bearing the optimized pyrazole. Fig 7 a. Apixaban (compound 12) b. In vitro Ki values of apixaban for FXa and other human enzymes with structural or functional similarities (figure extracted from [6]). c. Therapeutic index of apixaban and warfarin in rabbit models (figure extracted from [6]). Conclusion Comparing to the initial lead compound, the eventual drug changed dramatically in chemical structure, while its FXa inhibiting potency was enhanced by 107. Tracing back to each modification step, the comprehensive consideration in drug potency, selectivity, absorption, metabolism and toxicity is truly impressive and reveals the tremendous efforts embedded in a single drug. It is worth noting that molecular modeling with FXa structure played a critical role during the rational drug modification process. The discovery of apixaban also demonstrated the importance of defining new drug target in modern drug development. The success of apixaban is largely attributed to the better drug target FXa. However, the clinical trial of apixaban on acute coronary syndrome was discontinued due to increased bleeding events [6], which suggests that other anticoagulants are still in demand for treating various type of thrombosis. Reference [1] Pinto, D. J.; Orwat, M. J.; Koch, S.; Rossi, K. A.; Alexander, R. S.; Smallwood, A.; Wong, P. C.; Rendina, A. R.; Luettgen, J. M.; Knabb, R. M.; He, K.; Xin, B.; Wexler, R. R; Lam, P. Y. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl) phenyl)-4, 5, 6, 7-tetrahydro-1 H-pyrazolo [3, 4-c] pyridine-3-carboxamide (Apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.Journal of medicinal chemistry. 2007,50, 5339-5356. [2] Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Turner, M. B et al. Heart Disease and Stroke Statistics: 2013 Update: A Report From the American Heart Association. Circulation. 2013, 127, 143-146. [3] Pallister, C. J.; Watson, M. S. Haematology, 2nd ed. Scion Publishing: Banbury, 2010; pp 336–347. [4] Krishnaswamy, S. Exositeà ¢Ã¢â€š ¬Ã‚ driven substrate specificity and function in coagulation. Journal of thrombosis and haemostasis. 2005, 3, 54-67. [5] Hirsh, J., Fuster, V., Ansell, J., Halperin, J. L. Foundation guide to warfarin therapy. Journal of the American College of Cardiology. 2003, 41, 1633-1652. [6] Wong, P. C.; Pinto, D. J.; Zhang, D. Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor.Journal of thrombosis and thrombolysis. 2011,31, 478-492. [7] Quan, M. L.; Pruitt, J. R.; Ellis, C. D.; Liauw, A. Y.; Galemmo, R. A., Jr.; Stouten, P. F. W.; Wityak, J.; Knabb, R. M.; Thoolen, M. J.; Wong, P. C.; Wexler, R. R. Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors.Bioorganic Medicinal Chemistry Letters. 1997, 7, 2813-2818. [8] Quan, M. L.; Liauw, A. Y.; Ellis, C. D.; Pruitt, J. R.; Carini, D. J.; Bostrom, L. L.; Huang, P. P.; Harrison, K.; Knabb, R. M.; Thoolen, M. J.; Wong, P. C.; Wexler, R. R. Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors 1. Journal of medicinal chemistry. 1999,42, 2752-2759. [9] Quan, M. L.; Ellis, C. D.; Liauw, A. Y.; Alexander, R. S.; Knabb, R. M.; Lam, G.; Wright, M. R.; Wong, P. C.; Wexler, R. R. Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors 2. Journal of medicinal chemistry. 1999,42, 2760-2773. [10] Pruitt, J. R., Pinto, D. J., Estrella, M. J., Bostrom, L. L., Knabb, R. M., Wong, P. C. Wright, M. R., Wexler, R. R. Isoxazolines and isoxazoles as factor Xa inhibitors.Bioorganic medicinal chemistry letters,2000, 10, 685-689. [11] Pinto, D. J.; Orwat, M. J.; Wang, S.; Fevig, J. M.; Quan, M. L.; Amparo, E.; Cacciola, J.; Rossi, K. A.; Alexander, R. S.; Smallwood, A. M.; Luettgen, J. M.; Liang, L.; Aungst, B. J.; Wright, M. R.; Knabb, R. M.; Wong, P. C.; Wexler, R. R.; Lam, P. Y. Discovery of 1-[3-(Aminomethyl) phenyl]-N-[3-fluoro-2-(methylsulfonyl)-[1, 1-biphenyl]-4-yl]-3-(trifluoromethyl) -1H-pyrazole-5- carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa 1.Journal of medicinal chemistry. 2001, 44, 566-578. [12] Pinto, D. J.; Orwat, M. J.; Quan, M. L.; Han, Q.; Galemmo, R. A., Jr.; Amparo, E.; Wwllsg, B.; Ellisj, C.; Hek, M. Y.; Alexanderf, R. S.; Knabbb, R. M.; Mersingerg, L.; Kettnera, C.; Baih, S.; Hed, K. Wexlera, R. R.; Lam, P. 1-[3-Aminobenzisoxazol-5†²-yl]-3-trifluoromethyl -6-[2†²-(3-(R) -hydroxy-N-pyrrolidinyl) methyl-[1, 1†²]-biphen-4-yl]-1, 4, 5, 6-tetrahydropyrazolo-[3, 4-c]-pyridin -7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.Bioorganic medicinal chemistry letters. 2006,16, 4141-4147.

Narrative Essay: she always laughs... :: Example Personal Narratives

she always laughs... Suicide makes me think of my grandmother and uncle whom I never met. Each took their lives before I was born. I spoke with my mother about Grandma Ruth yesterday evening. She delights in telling me how much Grandma Ruth would have loved me. We didn't talk about her often. She died when my mother was a junior in high school. My mother always refered to her as "my mother", so it wasn't until I was a teen that I came up with a name for her. My grandfathers are called by their last names: Grandpa P. and Grandpa R. My other grandmother was called Amah and her husband was Poppa. One day I had a question about my mother's mother and I refered to her as Grandma Ruth. That has been what we have called her ever since. Apparently, on the day she died, she woke up in the morning and gave her husband a dollar, instructing him to send their oldest child to college. Then she took the bus to the bridge where she jumped. My grandfather saved that dollar all these years, but has lost it in the past decade. We have four possessions which formerly belonged to Grandma Ruth. She was schizophrenic and spent half of every year in a mental hospital; we have a sock doll she made in the institution. We have a wonderful pair of green sunglasses she wore; both of the nose pieces are broken off. My grandfather had her wedding ring made into a necklace, which he gave to my mother a few years ago. The fourth item is a large gold cross. The voice my grandmother heard in her head was the voice of god. It was no doubt the voice that told her that she needed to leave this planet. Grandma Ruth and I would have gotten along so well. I would have curled up on a chair in the kitchen while she baked cookies. We would have laughed and gossiped and she would have put flowers in my hair. I would have squaled with a giddy happiness every time she began a story with, "When your mother was little..." I don't know many stories about when my mother was little. She has forgotten most everything, and even now her memory is terrible.